Fall 2008 LECTURE SCHEDULE: 01-146:470 + 16-148:514
Course coordinator: Prof. David Denhardt (Nelson, A301, (denhardt@biology.rutgers.edu)
Faculty: Prof. Ron Hart (rhart@rci.rutgers.edu);
Prof. Charles Martin (martin@biology.rutgers.edu);
Prof.Martin Grumet (mgrumet@rci.rutgers.edu);
Prof. Beatrice Haimovich (haimovic@umdnj.edu);
Prof. Gary Brewer (brewerga@umdnj.edu);
Prof. Guy Werlen (werlen@biology.rutgers.edu);
Prof. Barth Grant (grant@biology.rutgers.edu); Prof. Yacov Ron (yron@umdnj.edu).
First period (8:40-10:00 AM) Monday and Thursday, Fall semester - SEC 118.
The text is MOLECULAR CELL BIOLOGY by Lodish, Berk, Matsudaira, Kaiser, et al. 6ed, WH Freeman.
Website access: http://lifesci.rutgers.edu/~denhardt/course/cellmolbiol.htm
(for Dr. Hart’s lectures it is: http://spine.rutgers.edu/cellbio/default.htm.
September 4 - Course overview; review of cell structure and function DTD (Chapters 1, 2) PPT PDF
September 8 - Nucleic acid structure and function, RH (4.1 – 4.4)
September 11 - DNA replication and repair, RH (4.5 – 4.6)
September 15 - Methods to study and manipulate DNA and proteins RH (5.1 - 5.3)
September 18 –The Cell Cycle, DTD (Chapter 20.1 – 20.7) PDF PPT Homework
September 22–Methods to study and manipulate DNA and proteins RH (5.4 - 5.5)
September 25 - Chromatin structure and mobile genetic elements RH (6.1 – 6.3, 6.6)
September 29 - Genomics RH (6.5)
October 2 - Protein structure and function, CM (3.1-3.5) HMWK PDF PPT
October 6 - Exam #1 Grades
October 9 - Biomembranes, structure function, CM (Chapter 10, 13.1-13.3,13.6) HMWK PDF PPT
October 13 - Membrane Transport, CM (Chapter 11) HWMK PDF PPT
October 16 - Secretion BG (Chapter 9.1, 14.1-14.4) HMWK PDF PPT Golgi1 Golgi2 Keller uobf schmor rab5 sec secfus
October 20 - Endocytosis BG (Chapter 9.2-9.3, 14.5-14.6) HWMK PDF PPT clathrin
October 23 - Transcription, GB (Sections 7.1 – 7.8, 21.3, pp. 969-977) HMWK(4 lectures) PDF PPT
October 27 - RNA processing I, GB (Sections 8.1 through 8.3 and pp 357-367) PDF PPT
October 30 - RNA processing II, GB (pp.352-353 [“Degradation of mRNA and P Bodies”); section 13.6) PDF PPT
November 3 - Translation, GB (rev: 4.3,4,4; pp347-356; Sect 13.1; pp908-910; figs + legends in attached paper) PDF PPT Bartel review
November 6 - Immunity, YR (Chapter 24) HMWK PPT PDF
November 10 – Exam #2 Grades
November 13 - The Cytoskeleton, BH (Chapter 17) PPT PDF HMWK(all 3 lectures)
November 17 - Motor Proteins, BH (Chapter 17-18) PPT PDF
November 20 - Movement and Cell Motility, BH (Chapter 18). PPT PDF
November 24 – Signal Transduction I: (GW) Chapter 15: intro, 15.1, 15.2, 15.3, 15.4, 15.6, 15.7. HMWK PPT PDF
November 25 - Signal Transduction II: (GW) Chapter 16: intro, 16.2, 16.3, 16.4, 16.5, 16.7. PPT PDF
December 1 - Cell Junctions and Cell adhesion MG (Sections 9.5, 19.1, 19.2, 19.5) HMWK PPT PDF
December 4 - Extracellular Matrix/Neural Development MG (Sections 19.3, 19.4, 22.3, 22.5) PPT PDF
December 8 - Cancer, DTD (Chapter 25) HMWK PPT PDF
The third 80-min exam (#3) will be given at the time of the final exam (Friday Dec 19 from 4-5:20 PM).
Course evaluation: Please note that the powerpoint slides for each lecture can be accessed by clicking on the highlighted title; homework questions are accessed similarly. There will be three 80-min exams that will count for 80% of the grade. Before each lecture, students will submit to Dr. Denhardt or the lecturer brief answers to questions on the subject of the lecture. The quality of the students’ answers will count for 20% (undergraduates) and 10% (graduate students). The graduate students will be asked to write a 3-5-page paper on a topic of their choice. This paper, worth 10% of the final grade, must be submitted to the professor who will grade it no later than Thursday, Friday, Dec. 13. The paper may be on any subject covered by any of the lecturers. The format of the paper (e.g. a critical review of a subject or a critique of a paper) must be approved in advance by Dr. Denhardt and the professor who will grade it. A key part of the grade will be evidence of creative thinking, as opposed to simply a rehash of the literature, on the part of the student.