Kenneth H. McKeever Associate Professor Rutgers University Dept. Animal Sciences Bartlett Hall School of Env & Biol Sciences New Brunswick. NJ 08903 (732) 932-9390 FAX - 6996 mckeever@aesop.rutgers.edu

Comparative exercise and cardiovascular physiology

On a basic level. my research has focused on comparative exercise and cardiovascular physiology with a particular interest in baroreceptor function and renal and neuroendocrine control of blood pressure. blood volume. and fluid and electrolyte balance. On an applied level. my research has focused on the effects of ergogenic (performance-enhancing) practices on the physiological responses of the equine athlete. Research in the lab is focused on basic physiology of the equine athlete . Our mission is not to cure sick horses. but rather to enhance our understanding of the equine athlete and the physiology of prevent problems before they occur. There are many similarities between horses and humans and we are also using the horse as a model to study the effects of aging on a variety of physiological systems. Ultimately our goal is to provide information for horse owners around the world and to find new ways to make happier. healthier. horses.

Selected Publications

Manso Filho HC, Costa HE, Wang Y, McKeever KH, Watford M. (2008) Distribution of glutamine synthetase and an inverse relationship between glutamine synthetase expression and intramuscular glutamine concentration in the horse. Comp Biochem Physiol B Biochem Mol Biol. 150(3):326-30.

Manso Filho HC, McKeever KH, Gordon ME, Costa HE, Watford M. (2007) Novel findings regarding Glut-4 expression in adipose tissue and muscle in horses--a preliminary report. Vet J. 174(3):565-9.

Kearns CF. McKeever KH. Malinowski K. (2006) Changes in adipopnectin. leptin. and fat mass after clenbuterol treatment in horses. Med Sci Sports Exerc. 38(2):262-7.

Gordon ME. McKeever KH. Betros CL. Manso Filho HC. (2006) Exercise-induced alterations in plasma concentrations of ghrelin. adiponectin. leptin. glucose. insulin. and cortisol in horses. Vet J. 173(3):532-40.

Gordon ME. McKeever KH. Betros CL. Manso Filho HC. (2005) Plasma leptin. ghrelin and adiponectin concentrations in young fit racehorses versus mature unfit standardbreds. Vet J. 173(1):91-100.

Kearns CF. McKeever KH. Roegner V. Brady SM. Malinowski K. (2005) Adiponectin and leptin are related to fat mass in horses. Vet J. 172(3):460-5.

McKeever. K.H (2004). Physiology of body fluids in the equine athlete. Equine Sports Medicine and Surgery:Basic and Clinical Sciences of the Equine Athlete Eds: K. Hinchcliff. A. Kaneps. R. Geor. Elsevier. Philadelphia. Chpt. 38. p. 853-871.

McKeever. K. & Gordon. M. (2004) Endocrine alterations in the equine athlete. Equine Sports Medicine and Surgery: Basic and Clinical Sciences of the Equine Athlete Eds: K. Hinchcliff. A. Kaneps. R. Geor. Elsevier. Philadelphia. Chpt. 35. pp. 793-814.

Malinowski. K. Kearns. C.F.. Guirnalda. P.D.. Roegner. V. and McKeever. K.H. (2004). Effect of chronic clenbuterol administration on immune function in horses. J Animal Sci. 82: 3500-3507.

Abe. T. Kearns. C.F.. Manso Filho. H.C.. Sato. Y.. Sleeper. M.. McKeever. K.H. (2004). Moderate vascular occlusion produced acute increases in skeletal muscle size and clinical blood parameters in Standardbred horses. Equine and Comparative Exercise Physiology 1:239-243.

Lehnhard. R.A.. McKeever. K.H.. Kearns. C. F. and Beekley. M. D. (2004). Aging- related changes in fat free mass and myosin heavy chain in Standardbred mares. The Veterinary Journal 167: 59-66.

McKeever. K.H (2003). Aging and how it affects the physiological response to exercise in the horse. Clinical techniques in equine practice - sports medicine/exercise physiology series 2 (3): 258-265.

McKeever. K.H. (2003). Overtraining Syndrome In Standardbred Horses: New Insight into the Role of Red Blood Cell Hypervolemia The Veterinary Journal 165:190-192.

Plant. D.R.. Kearns. C.F.. McKeever. K.H.. Lynch. G.S. (2003).
Short-term clenbuterol treatment does not affect Ca2+-sensitivity of fast skeletal muscle fibers from horses. Journal of Muscle Research and Cell Motility 24:471-476.

Beekley. M.D.. Ideus. J.M.. Brechue. W.F.. Kearns. C.F.. McKeever. K.H. (2003). Chronic clenbuterol administration alters myosin heavy chain composition in Standardbred mares. The Veterinary Journal 165: 234-239.

McKeever. K.H (2002). Exercise physiology of the older horse. In: Veterinary Clinics of North America: Equine Practice; Geriatrics. edited by J.M. MacLeay. W.B. Saunders. Philadelphia. Vol. 18 (3):469-490.

McKeever. K.H (2002). Endocrine response to the challenge of exercise. In:Veterinary Clinics of North America: Equine Practice; Equine Endocrinology. eds Messer. N.T.. P.J. Johnson. Saunders. Philadelphia. Vol. 18:321-354.

Kearns. C.F. and McKeever. K.H. (2002). Clenbuterol disrupts central mechanisms of aerobic performance in the horse. Medicine and Science in Sport and Exercise 34:1976-1985.

Kearns. C.F.. McKeever. K.H.. Abe. T. (2002). Overview of horse body composition and muscle architecture- implications for performance. The Veterinary Journal 64:224-234.

Roche. B.M.. Schwartz. D.. Lehnhard. R.A.. McKeever. K.H.. Nakayama. T.. Kirby. T.E.. Robitaille. P-M.. Hamilin. R.L (2002). Changes in concentrations of neuroendocrine hormones and catecholamines in dogs with myocardial failure produced by rapid ventricular pacing. Am. J. Vet. Res. 63:1413-1417.

Kearns. C.F.. McKeever. K.H.. John-Alder. H.. Abe. T. and Brechue. W. (2002). Body composition and other predictors of maximal oxygen uptake. Equine Veterinary Journal Suppl. 34:485-490.

Malinowski. K.. Betros. C.L.. Flora. L.. Kearns. C.F. and McKeever. K.H. (2002). Effect of training on age-related changes in plasma insulin and glucose. Equine Veterinary Journal Suppl. 34:147-153.

Betros. C.L.. McKeever. K.H.. Kearns. C.F. and Malinowski. K. (2002). Effects of aging and training on maximal heart rate and VO2max Equine Veterinary Journal Suppl. 34:100-105.

McKeever. K.H.. Kearns. CF. and Antas. L.A. (2002). Endothelin response to exercise in horses. The Veterinary Journal 164:41-49.

McKeever. K.H.. Scali. R.. Geiser. S.. Kearns. C.F. (2002). Plasma aldosterone concentration and renal sodium excretion are altered during the first days of training in horses. Equine Veterinary Journal Suppl. 34:524-531.

Kearns. C.F.. McKeever. K.H. . Kumagai. K.. Abe. T. (2002). Fat-Free mass is related to one mile race performance in elite Standardbred horses. The Veterinary Journal 163:260-266.

Sleeper. M.. Kearns. C.F. and McKeever. K.H. (2002). Chronic clenbuterol administration negatively alters cardiac function in the horse. Medicine and Science in Sport and Exercise 34:643-650.